( Gandolfo et al., 2003 Schiefer and Sparing, 2005 Tsai et al., 2009 Larner, 2017). phosphodiesterase inhibitors) has been previously documented. Yet, the association of TGA with various drugs (e.g. ( Werner et al., 2020 Ramanathan and Wachsman, 2021 Hornick et al., 2022). An increased incidence of TGA has been suggested since the beginning of the COVID-19 pandemic, but still has to be confirmed, pertaining to COVID-19 infection itself or the stress induced by the constraints endured by the population. The pathophysiology of TGA remains unclear, although several hypotheses are being explored, such as cerebrovascular, migrainous and epileptic mechanisms ( Szabo, 2014). With an incidence ranging between three and eight per 1,00 ,000 people per year, TGA mostly affects people aged 50–70 years ( Bartsch and Deuschl, 2010) with a possible influence of gender. In 1990, relevant specific criteria enabled a standardized assessment of TGA. Other cognitive functions are preserved and TGA episodes resolve spontaneously within 24 h ( Arena and Rabinstein, 2015). Transient global amnesia (TGA) is a clinical syndrome characterized by the sudden onset of anterograde amnesia (the inability to form new memories) with some degree of retrograde amnesia. As the safety of authorized vaccines continues to be closely monitored, a signal emerged recently regarding five cases of transient global amnesia following mRNA vaccination with elasomeran. Their rapid development was driven by previous experience with various vaccine platforms, investments in new technologies and an accelerated process of efficacy studies. Indeed, by the end of 2020, several vaccines became available. It spread rapidly, resulting in a global pandemic for which specific vaccines were soon developed. The identification of this trigger of TGA may help the clinician in his etiological research.Īt the end of 2019, in China, a cluster of viral pneumonia cases developed, later identified as COVID-19 (Coronavirus disease 2019). Yet, numerous confounding factors cannot be tackled with this approach, and causality cannot be ascertained. ![]() Cerebrovascular, inflammatory, or migrainous mechanisms may underlie this association. ![]() Our analysis of COVID-19 vaccines-related TGA reports shows significant disproportionality. With an IC025 > 0, COVID-19 vaccines showed a significant ROR (5.1 95%CI 4.4–6.0). Of all TGA cases, 289 were associated with a COVID-19 vaccine, representing the most frequent association. A positive lower end of the 95% CI of the IC (IC025) is used to statistically detect a signal. Disproportionality analysis relied on the Reporting Odds Ratio (ROR) with its 95% Confidence Interval (CI) and the Information Component (IC). We queried the World Health Organization VigiBase ® for all reports of “Transient global amnesia”, up to 6 December 2021. We aimed to investigate the potential link of TGA with COVID-19 vaccines. TGA is characterized by sudden onset of anterograde amnesia with preservation of other cognitive functions and resolution within 24 h. As their safety continues to be monitored, cases of transient global amnesia (TGA) following mRNA vaccination with elasomeran have been reported. ![]()
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